HUMAN CELL DESIGN
A Powerhouse Player in the Biotechnology Industry
Human Cell Design experts help you deliver better therapies to patients faster. At Human Cell Design, we assist industrials and academic groups by providing unique physiologically relevant human cell models.
TRULY TRANSLATIONAL HUMAN CELL MODELS
Getting better medication to patients faster
Here at Human Cell Design, we are convinced that human cell models are the way forward to getting better medication to patients faster. Our customers in the pharmaceutical and biotech industries and in academia rely on our internationally recognized human cells to generate reproducible data and to make informed decisions early in the drug development process.
HUMAN BETA CELLS, OUR FIRST ACCOMPLISHMENT
Validated by over 200 international institutions
Human Cell Design EndoC-βH pancreatic beta cells already led to major findings published in peer reviewed journals.
NATLINE®: A PATENTED CELL MATURATION PLATFORM
For large scale production of functional human cells
To overcome the current bottlenecks of human cell modelling, Human Cell Design combines human iPSc and primary cell technologies with its proprietary maturation platform NatLine®. NatLine® amplifies and maturates human progenitor cells to provide unlimited quantities of truly mature and fully functional human cells. The produced terminally differentiated cells replicate native healthy or diseased adult human cells.
Featured Products
EndoC-βH5® – EndoC-βH5® cells physiological and functional characteristics are highly similar to those of native human pancreatic beta cells. They represent an invaluable tool to better understand human beta cell physiology, function, proliferation and apoptosis, and a major improvement compared to previous EndoC-βH versions and other beta cell models. EndoC-βH5® cells display robust GLP-1 and GIP receptor activity associated with insulin content and glucose stimulated insulin secretion levels, close to those of native human beta cells.
EndoC-βH3® – EndoC-βH3® human pancreatic beta cell line is an intermediate version of EndoC-βH® cells. EndoC-βH3® cells are conditionally immortalized and de-immortalization leads to an increase in insulin content and secretion. EndoC-βH3® cells thus represent a translational tool to study beta cell proliferation and apoptosis.
EndoC-βH1® – This high-quality human pancreatic beta cell line displays a homogeneity that exceeds 99% and an insulin content of 0.5 to 1 µg/million cells. Functionality of EndoC-βH1® cells has been validated using glucose stimulated insulin secretion (GSIS) assay. Our production and assay processes are conducted with rigor and precision, in full respect of the industry’s highest quality standards for reliability and reproducibility. Below are the technical data of EndoC-βH1® characteristics.
HLA-A2 EndoC-βH5® – T-cell-mediated autoimmunity leading to beta cell death is a key factor in the progression of Type I diabetes. HLA-A2 EndoC-βH5® is a unique human cell model that robustly recapitulates the pathophysiology of T-cell mediated autoimmunity related to Human Type 1 diabetes. The histocompatibility antigen HLA-A*02 is a critical marker present on pancreatic beta cells of a large number of type 1 diabetic patients. HLA-A2 EndoC-βH5® is a cellular model expressing HLA-A*02 that can replicate in vitro the recognition and destruction of beta cells by CD8+ cytotoxic T cells. HLA-A2 Endoc-BH5® offers a unique solution to combine T-cell killing attack with measuring the indirect impact on insulin secretion and function loss.
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Services
ASSAY DEVELOPMENT
Our human cellular models can be customized to fit your specific needs. Human Cell Design team, with its extensive expertise in gene expression modulation strategies (genome editing, siRNA, shRNA) and reporter gene methods, will create the model that is adapted to your project and provide you with large quantities of your optimized human cellular model. Contact us to determine the most efficient readout and best strategy for your project. Our services combine technical expertise on the models and premium customized consulting and research services.
Cell Culture & Cell Banking
Human Cell Design experts have over 10 years of experience in cell production for the industry and have successfully developed cell production and banking solutions for even the most complex and sensitive cell lines. Our facilities comply with the highest international regulatory requirements: Biosafety Level 2 (BSL-2) laboratories, state of the art cell culture equipment with constant automated and human monitoring, comprehensive quality assurance and quality control systems. Hundreds of cell lines from various species and complexities have been successfully manipulated at Human Cell Design.
Contact Us
The Krishgen support team strives to provide swift responses and resolution to your queries.